The CNP comprises 8 components led by a team of 52 investigators representing diverse disciplines. The CNP team will execute five interlocking research projects supported by two research infrastructure cores and a coordinating center. Three research projects focus on clinical and laboratory approaches to understanding brain mechanisms underlying memory, response inhibition, and other behavioral functions disrupted in Schizophrenia, Bipolar Disorder, and Attention-Deficit/Hyperactivity Disorder. These projects examine variations in genetics, brain structure, brain function, and behavior in 2000 healthy people and 300 suffering from one of the target neuropsychiatric syndromes, and conduct parallel basic science experiments to unravel the biological mechanisms underlying these phenotypes. Development of new genome-wide analysis methods will capitalize on the large Northern Finland Birth Cohorts. Novel web-based software will be developed to visualize, model, and test interdisciplinary hypotheses spanning many levels of investigation. Collectively, the CNP establishes a new paradigm for interdisciplinary research to overcome obstacles in the study of neuropsychiatric syndromes and other complex biomedical disorders. Consortium for Neuropsychiatric Phenomics components and organization