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The CNP comprises 8
components led by a team of 52 investigators representing diverse
disciplines. The CNP team will execute five interlocking research
projects supported by two research infrastructure cores and a coordinating
center. Three research projects focus on clinical and laboratory
approaches to understanding brain mechanisms underlying memory,
response inhibition, and other behavioral functions disrupted in
Schizophrenia, Bipolar Disorder, and Attention-Deficit/Hyperactivity
Disorder. These projects examine variations in genetics, brain
structure, brain function, and behavior in 2000 healthy people
and 300 suffering from one of the target neuropsychiatric syndromes,
and conduct parallel basic science experiments to unravel the biological
mechanisms underlying these phenotypes. Development of new genome-wide
analysis methods will capitalize on the large Northern Finland
Birth Cohorts. Novel web-based software will be developed to visualize,
model, and test interdisciplinary hypotheses spanning many levels
of investigation. Collectively, the CNP establishes a new paradigm
for interdisciplinary research to overcome obstacles in the study
of neuropsychiatric syndromes and other complex biomedical disorders. |
Consortium
for Neuropsychiatric Phenomics components and organization
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