The Consortium for Neuropsychiatric Phenomics (CNP) advances the NIH Roadmap Initiative by assembling a transdisciplinary “research team of the future” to address major unsolved challenges in research on neuropsychiatric disorders. The CNP leverages the new discipline of phenomics – the systematic study of phenotypes on a genome-wide scale – by integrating basic, clinical and information sciences. Neuropsychiatric disorders have enormous public health significance, and there is currently a broad chasm between the basic and clinical research strategies used to study these disorders. The CNP breaks down artificial boundaries between psychiatric syndromes by studying important neuropsychological phenotypes that cut across diagnostic groups, and bridges basic and clinical sciences by studying these phenotypes across different species. The ultimate goals of the CNP are to facilitate discovery of the genetic and environmental bases of variation in psychological and neural system phenotypes, to elucidate the mechanisms that link the human genome to complex psychological syndromes, and to foster breakthroughs in the development of novel treatments for neuropsychiatric disorders. Vertical 7-Level Schema for the Consortium for Neuropsychiatric Phenomics